5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

Base Information

Chemical Name:5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide
CAS No.:913622-31-8
Molecular Formula:C₁₇H₁₇ClN₂O₇
Molecular Weight:396.784
Hs Code.:

Synonyms:5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

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Chemical Property of 5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

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Technology Process of 5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

There total 6 articles about 5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 913622-30-7
5-chloro-N-(3-formamido-6-methoxy-2,5-bis(methoxymethoxy)phenethyl)-2,4-dihydroxybenzamide

: 913622-31-8
5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In dichloromethane; acetonitrile; at 25 ℃; for 0.25h;
DOI:10.1021/jo061054f

Reference yield:

: 913622-80-7
3-(2-azidoethyl)-2-methoxy-1,4-bis(methoxymethoxy)-5-nitrobenzene

: 913622-31-8
5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / sodium sulfide; Et₃N / methanol / 12 h

2: 63 percent / DCC / tetrahydrofuran / 12 h / 50 °C

3: H₂ / Pd/C / ethyl acetate / 48 h

4: 17.4 mg / CH₂Cl₂ / 12 h / 30 °C

5: 76 percent / NaI; Me₃SiCl / CH₂Cl₂; acetonitrile / 0.25 h / 25 °C

With sodium sulfide; chloro-trimethyl-silane; hydrogen; triethylamine; dicyclohexyl-carbodiimide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jo061054f

Reference yield:

: 913622-27-2
2-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)ethanamine

: 913622-31-8
5-chloro-N-(3-formamido-2,5-dihydroxy-6-methoxyphenethyl)-2,4-dihydroxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / DCC / tetrahydrofuran / 12 h / 50 °C

2: H₂ / Pd/C / ethyl acetate / 48 h

3: 17.4 mg / CH₂Cl₂ / 12 h / 30 °C

4: 76 percent / NaI; Me₃SiCl / CH₂Cl₂; acetonitrile / 0.25 h / 25 °C

With chloro-trimethyl-silane; hydrogen; dicyclohexyl-carbodiimide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jo061054f