(2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

Base Information

Chemical Name:(2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone
CAS No.:1421707-07-4
Molecular Formula:C₃₃H₂₉ClFN₃OS
Molecular Weight:570.13
Hs Code.:

Synonyms:(2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

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Chemical Property of (2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

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Technology Process of (2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

There total 10 articles about (2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1-(2-chloropyridin-1-ium-4-carbonyl)-5-((4-fluorophenyl)thio)spiro[indoline-3,4'-piperidin]-1'-ium bis(2,2,2-trifluoroacetate)

: 104-55-2
3-phenyl-propenal

: 1421707-07-4
(2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: [4-(4-fluorophenyl)sulfanylphenyl]hydrazine hydrochloride

: 1421707-07-4
(2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18 h / 20 °C

1.2: 20.5 h / 0 - 20 °C

1.3: 1.5 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 - 20 °C

3.1: 1.5 h / 70 °C

4.1: triethylamine; sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

With sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 6313-54-8
2-chloroisonicotinic acid,

: 1421707-07-4
(2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 - 20 °C

3: 1.5 h / 70 °C

4: triethylamine; sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

With oxalyl dichloride; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;