3-methylidene-4-octyl-4,6a-dihydro-3aH-furo[3,4-b]furan-2,6-dione

Base Information

Chemical Name:3-methylidene-4-octyl-4,6a-dihydro-3aH-furo[3,4-b]furan-2,6-dione
CAS No.:20223-76-1
Molecular Formula:C15H22O4
Molecular Weight:266.33
Hs Code.:2932999099
NSC Number:179483
DSSTox Substance ID:DTXSID70942302
Nikkaji Number:J3.157.248G
Mol file:20223-76-1.mol

Synonyms:avenaciolide

Suppliers and Price of 3-methylidene-4-octyl-4,6a-dihydro-3aH-furo[3,4-b]furan-2,6-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-methylidene-4-octyl-4,6a-dihydro-3aH-furo[3,4-b]furan-2,6-dione

Chemical Property:

Vapor Pressure:1.4E-08mmHg at 25°C
Boiling Point:458.2°C at 760 mmHg
Flash Point:235.3°C
PSA：52.60000
Density:1.1g/cm³
LogP:2.76020
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:266.15180918
Heavy Atom Count:19
Complexity:374

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCC1C2C(C(=O)O1)OC(=O)C2=C
Uses Avenaciolide is a bicyclic bis-butyrolactone antifungal agent.

Technology Process of 3-methylidene-4-octyl-4,6a-dihydro-3aH-furo[3,4-b]furan-2,6-dione

There total 83 articles about 3-methylidene-4-octyl-4,6a-dihydro-3aH-furo[3,4-b]furan-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (3aR,4S,6aR)-6-Hydroxy-3-methylene-4-octyl-tetrahydro-furo[3,4-b]furan-2-one

: 16993-42-3,20223-76-1,26057-70-5,33644-09-6,50896-34-9,61474-24-6
(+/-)-isoavenaciolide

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In acetonitrile; Ambient temperature;
DOI:10.1016/0040-4020(95)00901-9

Reference yield: 75.0%

: 897657-60-2
(3aR,4R,6aR)-3-Methanesulfinyl-3-methyl-4-octyl-dihydro-furo[3,4-b]furan-2,6-dione

: 20223-76-1
(-)-avenaciolide

Guidance literature:: With succinic acid anhydride; at 140 ℃; for 1h;
DOI:10.1002/ejoc.200500961

Reference yield: 67.0%

: (3S,4S,5R)-3-hydroxy-4-(1-iodovinyl)-5-octyldihydrofuran-2(3H)-one

: 201230-82-2
carbon monoxide

: 3-methylene-4-octyl-dihydro-furo[3,4-b]furan-2,6-dione

: 20223-76-1
(-)-avenaciolide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 70 ℃; for 1h; under 76000 Torr;
DOI:10.1002/anie.200503863