(R)-7-phenylazepan-2-one

Base Information

Chemical Name:(R)-7-phenylazepan-2-one
CAS No.:1429410-81-0
Molecular Formula:C₁₂H₁₅NO
Molecular Weight:189.257
Hs Code.:

Synonyms:(R)-7-phenylazepan-2-one

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Chemical Property of (R)-7-phenylazepan-2-one

Chemical Property:

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Technology Process of (R)-7-phenylazepan-2-one

There total 4 articles about (R)-7-phenylazepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 4144-62-1
5-benzoylvaleric acid

: 1429410-81-0
(R)-7-phenylazepan-2-one

Guidance literature:: With titanium(IV) isopropylate; Ru⁽²⁺⁾*2C₂H₃O₂^(1-)*C₇₇H₁₀₈O₆P₂; ammonium acetate; hydrogen; In 2,2,2-trifluoroethanol; at 90 ℃; for 24h; enantioselective reaction; Autoclave;
DOI:10.1021/acs.orglett.0c00669

Reference yield:

: C₁₈H₂₉NO₃S

: 1429410-81-0
(R)-7-phenylazepan-2-one

Guidance literature:: C₁₈H₂₉NO₃S; With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃;

With sodium methylate; In methanol; diethyl ether; at 0 - 20 ℃;
DOI:10.1021/jo400164y

Reference yield:

: 4248-25-3
ethyl 6-oxo-6-phenylhexanoate

: 1429410-81-0
(R)-7-phenylazepan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / 72 °C / Inert atmosphere

2.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 2-Amino-2-methyl-1-propanol; potassium tert-butylate / isopropyl alcohol / 50 °C / Molecular sieve

3.1: hydrogenchloride / diethyl ether; methanol / 0 - 20 °C

3.2: 0 - 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; In methanol; diethyl ether; isopropyl alcohol;
DOI:10.1021/jo400164y