4248-25-3

Basic information

• Product Name: ETHYL 6-OXO-6-PHENYLHEXANOATE
• Synonyms: ETHYL 6-OXO-6-PHENYLHEXANOATE
• CAS NO: 4248-25-3
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.29
• Mol File: 4248-25-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 338.7°C at 760 mmHg
• Flash Point: 147°C
• Appearance: /
• Density: 1.048g/cm³
• Vapor Pressure: 9.66E-05mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: ETHYL 6-OXO-6-PHENYLHEXANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-OXO-6-PHENYLHEXANOATE(4248-25-3)
• EPA Substance Registry System: ETHYL 6-OXO-6-PHENYLHEXANOATE(4248-25-3)

Safety Data

• Hazardous Substances Data: 4248-25-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H18O3/c1-2-17-14(16)11-7-6-10-13(15)12-8-4-3-5-9-12/h3-5,8-9H,2,6-7,10-11H2,1H3

Upstream product

• 1444-65-1 (RS)-2-phenylcyclohexanone 
• 64-17-5 ethanol 
• 626-86-8 adipinic acid monoethyl ester 
• 98-80-6 phenylboronic acid 
• 1021934-34-8 ethyl 5-bromo-6-hydroxy-6-phenylhexanoate 
• 16717-64-9 1-azidostyrene 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 36103-31-8 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl acetate 
• 98-86-2 acetophenone 
• 78647-27-5 ethyl 5-ethylthiocarbonylpentanoate 
• 41302-32-3 ethyl 5-iodopentanoate 
• 1484-17-9 S-ethyl thiobenzoate 
• 109976-46-7 (5-ethoxy-5-oxopentyl)zinc(II) iodide 
• 1968-40-7 ethyl 4-pentenoate 

Downstream Products

• 250601-74-2 ethyl (E)-6-{3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-6-phenylhexanoate 
• 250602-32-5 ethyl (E)-6-(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate 
• 1429410-85-4 (S)-7-phenylazepan-2-one 
• 1429410-81-0 (R)-7-phenylazepan-2-one 
• 250601-56-0 ethyl (E)-6-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-6-phenylhexanoate 
• 342636-37-7 Ethyl ε-[(E)-2-(4-Bromophenyl)hydrazono]benzenehexanoate 
• 342636-43-5 ethyl 5-Methyl-2-phenyl-1H-indole-3-butanoate 
• 342636-38-8 ethyl 5-Chloro-2-(4-fluorophenyl)-1H-indole-3-propionate 
• 17924-66-2 phenyl-6 hexene-5 ol-1 (E) 
• 111820-53-2 (S)-2-((3S,7S)-1-tert-Butoxycarbonylmethyl-2-oxo-7-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid ethyl ester 
• 111820-59-8 (S)-2-((3R,7S)-1-tert-Butoxycarbonylmethyl-2-oxo-7-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid ethyl ester 
• 111820-52-1 (S)-2-((3S,7R)-1-tert-Butoxycarbonylmethyl-2-oxo-7-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid ethyl ester 
• 111820-60-1 (S)-2-((3R,7R)-1-tert-Butoxycarbonylmethyl-2-oxo-7-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid ethyl ester 

Relevant articles and documents

Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones

Vinyl azides are very reactive species and as such are useful building blocks, in particular, in the synthesis of N-heterocycles. They can also serve as precursors of ketones. These form in reactions of vinyl azides with nucleophiles or radicals. We have found, however, that under light irradiation vitamin B12 catalyzes the reaction of vinyl azides with electrophiles to afford unsymmetrical carbonyl compounds in decent yields. Mechanistic studies revealed that alkyl radicals are key intermediates in this transformation.

Photoredox Reaction of 2-Mercaptothiazolinium Salts with Silyl Enol Ethers

A method for the generation of free radicals from thiazolinium salts upon photocatalytic reduction is described. The thiazolinium salts are generated by treatment with methyl triflate of 2-mercaptothiazolines, which can be readily obtained from alkyl bromides and tosylates via a nucleophilic substitution reaction or by hydrothiolation of alkenes. Silyl enol ethers were used to trap the radicals, furnishing ketones after successive single-electron oxidation and elimination of the silyl cation.

Intermolecular Photocatalyzed Heck-like Coupling of Unactivated Alkyl Bromides by a Dinuclear Gold Complex

A practical protocol for a photocatalyzed alkyl-Heck-like reaction of unactivated alkyl bromides and different alkenes promoted by dinuclear gold photoredox catalysis in the presence of an inorganic base is reported. Primary, secondary, and tertiary unactivated alkyl bromides with β-hydrogen can be applied. Esters, aldehydes, ketones, nitriles, alcohols, heterocycles, alkynes, alkenes, ethers, and halogen moieties are all well tolerated. In addition to 1,1-diarylalkenes, silylenolethers and enamides can also be applied, which further increases the synthetic potential of the reaction. The mild reaction conditions, broad substrate scope, and an excellent functional-group tolerance deliver an ideal tool for synthetic chemists that can even be used for challenging late-stage modifications of complex natural products.