5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

Base Information

Chemical Name:5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide
CAS No.:1445853-64-4
Molecular Formula:C₂₇H₃₈N₂O₆
Molecular Weight:486.609
Hs Code.:

Synonyms:5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

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Chemical Property of 5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

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Technology Process of 5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

There total 11 articles about 5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1445854-27-2
ethyl 2-(2-carbamoyl-4-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)phenoxy)acetate

: 1445853-64-4
5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

Guidance literature:: With hydroxylamine; potassium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 48h;
DOI:10.1016/j.bmc.2015.05.011

Reference yield:

: 176240-84-9
methyl 4-(benzyloxy)-3-bromobenzoate

: 1445853-64-4
5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: Inert atmosphere

2.1: boron trifluoride diethyl etherate / Inert atmosphere

3.1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / Inert atmosphere

4.1: potassium carbonate / Inert atmosphere

5.1: sodium tetrahydroborate / Inert atmosphere

6.1: lithium hydroxide / Inert atmosphere

7.1: oxalyl dichloride / Inert atmosphere

7.2: Inert atmosphere

8.1: palladium; hydrogen

9.1: potassium carbonate / Inert atmosphere

10.1: hydroxylamine; potassium hydroxide / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; 1,3-bis-(diphenylphosphino)propane; hydrogen; hydroxylamine; palladium diacetate; potassium carbonate; palladium; triethylamine; potassium hydroxide; lithium hydroxide;

Reference yield:

: 1445854-17-0
4-(3-(4-(benzyloxy)-3-bromophenyl)pentan-3-yl )-2-methylphenol

: 1445853-64-4
5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)-pentan-3-yl)-2-(2-(hydroxyamino)-2-oxoethoxy)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / Inert atmosphere

2.1: potassium carbonate / Inert atmosphere

3.1: sodium tetrahydroborate / Inert atmosphere

4.1: lithium hydroxide / Inert atmosphere

5.1: oxalyl dichloride / Inert atmosphere

5.2: Inert atmosphere

6.1: palladium; hydrogen

7.1: potassium carbonate / Inert atmosphere

8.1: hydroxylamine; potassium hydroxide / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; hydrogen; hydroxylamine; palladium diacetate; potassium carbonate; palladium; triethylamine; potassium hydroxide; lithium hydroxide;