(S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

Base Information

Chemical Name:(S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate
CAS No.:360059-35-4
Molecular Formula:C₃₃H₃₅IN₂O₇
Molecular Weight:698.555
Hs Code.:

Synonyms:(S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

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Chemical Property of (S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

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Technology Process of (S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

There total 4 articles about (S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 360059-34-3
tert-butyl 4-iodo-3-methylaminomethylbenzoate

: 145038-53-5
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid

: 360059-35-4
(S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 1h;
DOI:10.1021/ol016258r

Reference yield:

: 52107-87-6
4-iodo-3-methylbenzoic acid

: 360059-35-4
(S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / DMAP / 2-methyl-propan-2-ol / 0.5 h / 20 °C

2: NBS; (PhCO)2O / CCl₄ / 48 h / Heating

3: 18.3 g / H₂O; tetrahydrofuran / 1 h / 20 °C

4: 75 percent / DCC; HOBT / CH₂Cl₂ / 1 h

With dmap; N-Bromosuccinimide; benzotriazol-1-ol; benzoic acid anhydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol016258r

Reference yield:

: 3-bromomethyl-4-iodo-benzoic acid tert-butyl ester

: 360059-35-4
(S)-tert-butyl 3-(N-Fmoc-aspartate-β-methyl ester-N-methyl)-amino-methyl-4-iodo-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 18.3 g / H₂O; tetrahydrofuran / 1 h / 20 °C

2: 75 percent / DCC; HOBT / CH₂Cl₂ / 1 h

3: aq. NaOH / 2-methyl-propan-2-ol

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol016258r