52107-87-6

Basic information

• Product Name: 4-IODO-3-METHYLBENZOIC ACID
• Synonyms: 4-IODO-M-TOLUIC ACID;4-IODO-3-METHYLBENZOIC ACID
• CAS NO: 52107-87-6
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Acids & Esters;Iodine Compounds
• Mol File: 52107-87-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 223-225°C
• Boiling Point: 327.7 °C at 760 mmHg
• Flash Point: 152 °C
• Appearance: /
• Density: 1.868 g/cm³
• Vapor Pressure: 8.05E-05mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.09±0.10(Predicted)
• CAS DataBase Reference: 4-IODO-3-METHYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-3-METHYLBENZOIC ACID(52107-87-6)
• EPA Substance Registry System: 4-IODO-3-METHYLBENZOIC ACID(52107-87-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: LIGHT SENSITIVE
• Hazardous Substances Data: 52107-87-6(Hazardous Substances Data)

Usage

General Description

4-Iodo-3-methylbenzoic acid is a chemical compound with the molecular formula C8H7IO2. It is a derivative of benzoic acid, with an iodo and a methyl group attached to the benzene ring. 4-IODO-3-METHYLBENZOIC ACID is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry to create various drugs and pharmaceutical intermediates. It is also known for its role in the production of dyes, fragrances, and agrochemicals. 4-Iodo-3-methylbenzoic acid is considered to be a hazardous substance and should be handled and disposed of with proper care according to safety guidelines.

InChI:InChI=1/C8H7IO2/c1-5-4-6(8(10)11)2-3-7(5)9/h2-4H,1H3,(H,10,11)

Upstream product

• 52107-80-9 1-(4-iodo-3-methyl-phenyl)-ethanone 
• 866996-02-3 4-ethyl-1-iodo-2-methyl-benzene 
• 4214-28-2 1-iodo-2,4-dimethylbenzene 
• 7697-37-2 nitric acid 
• 78881-21-7 4-amino-3-methylbenzonitrile 
• 2486-70-6 4-amino 3-methylbenzoic acid 
• 7681-65-4 copper(I) iodide 

Downstream Products

• 46194-50-7 4-iodo-isophthalic acid 
• 360059-33-2 tert-butyl 4-iodo-3-methyl-benzoate 
• 5471-81-8 methyl 4-iodo-3-methylbenzoate 
• 908247-61-0 3-methyl-4-(3,3,3-trifluoroprop-1-ynyl)benzoic acid 
• 269409-74-7 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid 
• 1019638-91-5 3,4,5-tris(octadecyloxy)benzyl 4-iodo-3-methylbenzoate 
• 1160924-22-0 1-(4-iodo-3-methylbenzoyl)-4-methylpiperazine 
• 444068-62-6 4-(5-FORMYL-FURAN-2-YL)-3-METHYL-BENZOIC ACID 

Relevant articles and documents

Acidity of benzoic acids bearing the (CO)5Cr=CN(CH 3)2 group

Benzoic acids 2a and 2b, bearing the (CO)5Cr=CN(CH 3)2 group in the p- and m-position, and the corresponding benzoic acids 2c and 2d, in which the rotation of the aminocarbene moiety was blocked by the presence of a methyl group, were prepared together with the corresponding N,N-dimethylamido acids 3a-d. The measurement of pKa values in EtOH and DMF revealed that the (CO)5Cr=CN(CH 3)2 group is a very weak electron acceptor (δp = 0; δm = 0.14). The restriction of the rotation of the aminocarbene moiety did not significantly influence its electronic properties. The obtained results are in accordance with earlier findings that the relatively strong acidity of carbene complexes bearing hydrogens at the ±-position to the carbene atom is due to the resonance stabilization of the anion.

Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (1): STR1 in which X is one of the radicals: STR2 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.