[4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

Base Information

Chemical Name:[4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid
CAS No.:950502-40-6
Molecular Formula:C₂₂H₂₅Cl₂NO₄
Molecular Weight:438.351
Hs Code.:

Synonyms:[4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

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Chemical Property of [4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

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Technology Process of [4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

There total 3 articles about [4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₉Cl₂NO₄

: 950502-40-6
[4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

Guidance literature:: C₂₄H₂₉Cl₂NO₄; With lithium hydroxide; water; In tetrahydrofuran; for 18h;

With water; acetic acid; In tetrahydrofuran; pH=~ 4;

Reference yield:

: 73401-74-8
4-hydroxymethylphenylacetic acid

: 950502-40-6
[4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetyl chloride / 18 h

2.1: manganese(IV) oxide / dichloromethane / 18 h

3.1: acetic acid; trimethyl orthoformate / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 18 h

4.1: dichloromethane / 18 h / 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 18 h

5.2: pH ~ 4

With manganese(IV) oxide; lithium hydroxide; water; acetic acid; acetyl chloride; trimethyl orthoformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 155380-11-3
methyl 4-(hydroxymethyl)phenylacetate

: 950502-40-6
[4-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / dichloromethane / 18 h

2.1: acetic acid; trimethyl orthoformate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 18 h

3.1: dichloromethane / 18 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 18 h

4.2: pH ~ 4

With manganese(IV) oxide; lithium hydroxide; water; acetic acid; trimethyl orthoformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;