155380-11-3Relevant articles and documents
SS-AMINO ACID DERIVATIVE, KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND USE OF THE SAME
-
Paragraph 0061; 0096-0097, (2021/07/08)
A compound represented by Formula (I), a pharmaceutically acceptable salt or ester, hydrate, solvate or crystalline form thereof is provided: The compound represented by Formula (I) is a β-amino acid derivative, and in Formula (I): X is a single bond or O; Y is NH or C=O; Z is C=O, C=S, NH, W is C or N; A is a single bond, O, OH, OCH2, a heterocycle or N3; R1 is H or F; R2 is H, F, OH, CF3, CH2OH, CHO or ; R3 is H; n is 0 or 1; and m is 0 or 1.
IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME
-
Paragraph 00152-00153, (2019/03/05)
Imidazole-based anticancer agents and derivatives thereof, as well as methods of making and methods of using the same, are described. The imidazole-based anticancer agents are HDAC inhibitor compounds having a 1-(1H-imidazol-2-yl)ethan-1-one or 1-(1H-imidazol-2-yl)ethane-1- thione moiety.
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity
Travelli, Cristina,Aprile, Silvio,Rahimian, Reza,Grolla, Ambra A.,Rogati, Federica,Bertolotti, Mattia,Malagnino, Floriana,Di Paola, Rosanna,Impellizzeri, Daniela,Fusco, Roberta,Mercalli, Valentina,Massarotti, Alberto,Stortini, Giorgio,Terrazzino, Salvatore,Del Grosso, Erika,Fakhfouri, Gohar,Troiani, Maria Pia,Alisi, Maria Alessandra,Grosa, Giorgio,Sorba, Giovanni,Canonico, Pier Luigi,Orsomando, Giuseppe,Cuzzocrea, Salvatore,Genazzani, Armando A.,Galli, Ubaldina,Tron, Gian Cesare
, p. 1768 - 1792 (2017/03/17)
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involved in the recycling of nicotinamide to maintain adequate NAD levels inside the cells. It has been postulated to be a pharmacological target, as it is overexpressed in cancer cells as well as in inflammatory diseases. We describe the synthesis and characterization of a novel class of one-digit nanomolar NAMPT inhibitors based on in vitro characterization. The most active compound tested, 30c, displayed activity in xenograft and allograft models, strengthening the potential of NAMPT inhibitors as antitumoral drugs. Furthermore, in the present contribution we describe the ability of 30c to significantly improve the outcome of colitis in mice. Given that this is the first report of an effect of NAMPT inhibitors in colitis, this result paves the way for novel applications for this class of compounds.