(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

Base Information

• Chemical Name: (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester
• CAS No.: 1352393-12-4
• Molecular Formula: C₁₉H₂₂BrNO₅
• Molecular Weight: 424.291

Synonyms:(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

Chemical Property of (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

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Technology Process of (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

There total 14 articles about (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester (1228215-18-6) + para-bromophenacyl bromide (99-73-0,132309-76-3) → (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (1352393-12-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 3h;

Reference yield: 90.0%

C11H19NO3 (1560646-40-3) + para-bromophenacyl bromide (99-73-0,132309-76-3) → (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (1352393-12-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 3h; Inert atmosphere; Saturated gas;

Reference yield: 90.0%

C13H18IN3O2 (1560646-48-1) + para-bromophenacyl bromide (99-73-0,132309-76-3) → (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (1352393-12-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 3h;

upstream raw materials:

(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester

para-bromophenacyl bromide

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

(S)-4-trifluoromethanesulfonyloxy-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Downstream raw materials:

6-((4-(2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-imidazol-5-yl)phenyl)ethynyl)-2-((S)-pyrrolidin-2-yl)-1H-benzo[d]imidazole

methyl N-[(2S)-1-[(2S)-2-{6-[2-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)ethynyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

(S)-tert-butyl 2-(5-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazol-2-yl)-4-methyl-2,5-dihydro-1H-pyrrole-1-carboxylate

2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

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