2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

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Chemical Name:2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole
CAS No.:1352393-43-1
Molecular Formula:C₃₁H₃₀N₆
Molecular Weight:486.619
Hs Code.:

Synonyms:2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

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Chemical Property of 2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

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Technology Process of 2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

There total 7 articles about 2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352393-42-0
(S)-tert-butyl 2-(5-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazol-2-yl)-4-methyl-2,5-dihydro-1H-pyrrole-1-carboxylate

: 1352393-43-1
2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 102195-80-2
(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

: 1352393-43-1
2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 3 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 95 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

3.2: pH 3

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; dimethyl sulfoxide / 2 h / 100 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; sodium hexamethyldisilazane; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; xylene;

Reference yield:

: 1228215-10-8
(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1352393-43-1
2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4-(6-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)naphthalen-2-yl)phenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; dimethyl sulfoxide / 2 h / 100 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; xylene;