2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

Base Information

Chemical Name:2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol
CAS No.:387871-65-0
Molecular Formula:C₃₈H₄₀N₂O₇
Molecular Weight:636.745
Hs Code.:

Synonyms:2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

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Chemical Property of 2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

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Technology Process of 2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

There total 8 articles about 2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 387871-64-9
2-benzoyloxymethyl-N-(tert-butyloxycarbonyl)-2-(4-methoxytrityloxy)methyl-N'-phthaloylpropane-1,3-diamine

: 387871-65-0
2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 2h;
DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A

Reference yield:

: 2425-41-4
5,5-dihydroxymethyl-2-phenyl-1,3-dioxane

: 387871-65-0
2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / pyridine / 3 h / 20 °C

2: 98 percent / triphenylphosphane; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

3: 81 percent / hydrazine monohydrate / ethanol / 20 °C

4: 88 percent / 2M NaOH / acetonitrile; H₂O / 20 °C

5: 72 percent / tert-butyl hydroperoxide / palladium acetate / benzene / 408 h / 20 °C

6: 96 percent / DEAD; triphenylphosphane / tetrahydrofuran / 48 h / 20 °C

7: 61 percent / sodium methoxide / methanol / 2 h / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; sodium methylate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; pyridine; methanol; ethanol; water; acetonitrile; benzene; 2: Mitsunobu reaction;
DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 387871-65-0
2-(tert-butyloxycarbonylamino)methyl-3-(4-methoxytrityloxy)-2-phthalimidomethylpropan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / pyridine / 3 h / 20 °C

2: 98 percent / triphenylphosphane; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

3: 81 percent / hydrazine monohydrate / ethanol / 20 °C

4: 88 percent / 2M NaOH / acetonitrile; H₂O / 20 °C

5: 72 percent / tert-butyl hydroperoxide / palladium acetate / benzene / 408 h / 20 °C

6: 96 percent / DEAD; triphenylphosphane / tetrahydrofuran / 48 h / 20 °C

7: 61 percent / sodium methoxide / methanol / 2 h / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; sodium methylate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; pyridine; methanol; ethanol; water; acetonitrile; benzene; 2: Mitsunobu reaction;
DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A