2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol

Base Information

• Chemical Name: 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol
• CAS No.: 387871-67-2
• Molecular Formula: C₄₅H₄₈N₂O₇
• Molecular Weight: 728.885

Synonyms:2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol

Chemical Property of 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol

There total 10 articles about 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 2-aminomethyl-2-[N-(tert-butyloxycarbonyl)amino]methyl-3-(4-methoxytrityloxy)propanol (387871-66-1) → 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol (387871-67-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A

Reference yield:

5,5-dihydroxymethyl-2-phenyl-1,3-dioxane (2425-41-4) → 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol (387871-67-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 55 percent / pyridine / 3 h / 20 °C

2: 98 percent / triphenylphosphane; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

3: 81 percent / hydrazine monohydrate / ethanol / 20 °C

4: 88 percent / 2M NaOH / acetonitrile; H₂O / 20 °C

5: 72 percent / tert-butyl hydroperoxide / palladium acetate / benzene / 408 h / 20 °C

6: 96 percent / DEAD; triphenylphosphane / tetrahydrofuran / 48 h / 20 °C

7: 61 percent / sodium methoxide / methanol / 2 h / 20 °C

8: 86 percent / hydrazine monohydrate / ethanol / 20 °C

9: 91 percent / DIPEA / dioxane / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; sodium methylate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; water; acetonitrile; benzene; 2: Mitsunobu reaction;

DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol (387871-67-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 55 percent / pyridine / 3 h / 20 °C

2: 98 percent / triphenylphosphane; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

3: 81 percent / hydrazine monohydrate / ethanol / 20 °C

4: 88 percent / 2M NaOH / acetonitrile; H₂O / 20 °C

5: 72 percent / tert-butyl hydroperoxide / palladium acetate / benzene / 408 h / 20 °C

6: 96 percent / DEAD; triphenylphosphane / tetrahydrofuran / 48 h / 20 °C

7: 61 percent / sodium methoxide / methanol / 2 h / 20 °C

8: 86 percent / hydrazine monohydrate / ethanol / 20 °C

9: 91 percent / DIPEA / dioxane / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; sodium methylate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; water; acetonitrile; benzene; 2: Mitsunobu reaction;

DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

2-aminomethyl-2-[N-(tert-butyloxycarbonyl)amino]methyl-3-(4-methoxytrityloxy)propanol

5,5-dihydroxymethyl-2-phenyl-1,3-dioxane

mono-4-methoxytrityl chloride

Downstream raw materials:

allyl 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propanoate

2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 387871-67-2 2-(tert-butyloxycarbonylamino)methyl-2-(9-fluorenylmethoxycarbonylamino)methyl-3-(4-methoxytrityloxy)propan-1-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send