4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Name:4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:1357478-54-6
Molecular Formula:C₂₀H₂₀N₆O₅S
Molecular Weight:456.482
Hs Code.:

Synonyms:4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of 4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 3 articles about 4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 226907-28-4
4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric Acid

: 1357478-54-6
4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Reference yield: 78.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 226907-28-4
4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric Acid

: 1357478-54-6
4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Reference yield:

: 226908-20-9
9-benzyl-8-hydroxy-2-mercaptoadenine

: 1357478-54-6
4-(6-Amino-9-benzyl-8-hydroxy-9H-purin-2-ylsulfanyl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere; Molecular sieve

1.2: 20 h / 25 °C / Inert atmosphere; Molecular sieve

2.1: potassium hydroxide / methanol; water / 48 h / 25 °C

3.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere; Molecular sieve

With potassium carbonate; dicyclohexyl-carbodiimide; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide;