2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

Base Information

Chemical Name:2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide
CAS No.:1383485-31-1
Molecular Formula:C₂₃H₂₄F₃N₅S
Molecular Weight:459.538
Hs Code.:

Synonyms:2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

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Chemical Property of 2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

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Technology Process of 2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

There total 3 articles about 2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1383485-14-0
1-cyclohexyl-2-(4-trifluoromethylphenyl)-5-acetyl-1H-benzimidazole

: 79-19-6
thiosemicarbazide

: 1383485-31-1
2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

Guidance literature:: With acetic acid; In ethanol; water; Reflux;
DOI:10.1016/j.ejmech.2012.03.038

Reference yield:

: 1368615-59-1
1-(3-amino-4-(cyclohexylamino)phenyl)ethanone

: 1383485-31-1
2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / water; N,N-dimethyl-formamide / 1 h / 20 °C

2: acetic acid / ethanol; water / Reflux

With Oxone; acetic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.03.038

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1383485-31-1
2-(1-(1-cyclohexyl-2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarbothioamide

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide / 3 h / 70 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C

3: Oxone / water; N,N-dimethyl-formamide / 1 h / 20 °C

4: acetic acid / ethanol; water / Reflux

With Oxone; palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.03.038