2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

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Chemical Name:2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate
CAS No.:1258975-62-0
Molecular Formula:C₂HF₃O₂*C₁₈H₁₈N₆OS
Molecular Weight:480.47
Hs Code.:

Synonyms:2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

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Chemical Property of 2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

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Technology Process of 2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

There total 4 articles about 2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1258976-24-7
1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo-[4,3-c]pyridine-5-carboxylate

: 76-05-1
trifluoroacetic acid

: 1258975-62-0
2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258975-62-0
2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / 90 °C

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 - 70 °C

3: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 160 °C / Microwave irradiation

4: dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With copper(l) iodide; tert.-butylnitrite; caesium carbonate; copper(ll) bromide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 1258440-55-9
5-(5-amino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]benzonitrile

: 1258975-62-0
2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 - 70 °C

2: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 160 °C / Microwave irradiation

3: dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With copper(l) iodide; tert.-butylnitrite; caesium carbonate; copper(ll) bromide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512