1258440-55-9

Upstream product

• 258273-31-3 3-cyano-4-isopropoxybenzoic acid 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1258854-13-5 5-(5-(2-(1,3-dihydroxypropan-2-yl)-5-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,3,4-thiadiazol-2-yl)-2-isopropoxybenzonitrile hydrochloride 
• 1258976-20-3 1,1-dimethylethyl 3-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]propanoate 
• 1258975-64-2 3-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)propanoic acid 
• 1258976-25-8 ethyl 3-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)propanoate 
• 1258976-35-0 tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate 
• 1258975-43-7 2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile 
• 1258975-62-0 2-[(1-methylethyl)oxy]-5-[5-(4,5,6,7-tetrahydro-2Hpyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]benzonitrile trifluoroacetate 
• 1258976-19-0 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate 
• 1258976-24-7 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo-[4,3-c]pyridine-5-carboxylate 
• 1258976-18-9 5-(5-hydrazino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)-oxy]benzonitrile 
• 1258975-66-4 4-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-butanoic acid 
• 1258976-26-9 ethyl 4-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butanoate 
• 1258855-41-2 2-isopropoxy-5-(5-(5-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,3,4-thiadiazol-2-yl)benzonitrile trifluoroacetate 
• 1258852-58-2 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3,4-dihydro-2(1H)-isoquinolinyl]propanamide 

Relevant academic research and scientific papers

S1P1 AGONIST AND APPLICATION THEREOF

The present invention relates to a class of tricyclic compounds and an application thereof as a sphingosine 1-phosphate type 1 (S1P1) receptor agonist. The invention specifically relates to a compound represented by formula (II), and a tautomer and pharmaceutically acceptable salt of same.

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses

FTY720 is the first oral small molecule approved for the treatment of people suffering from relapsing-remitting multiple sclerosis. It is a potent agonist of the S1P1 receptor, but its lack of selectivity against the S1P3 receptor ha

Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists

This article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P450 1A family during a lead optimization campaign for small molecule S1P1 agonists. Fold changes in mRNA up to 10 000-fold for CYP1A1 in vivo

THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated

THIADIAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF DISORDERS MEDIATED BY SLPL RECEPTORS

The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING

The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS

5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS

5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.