4'-isobutylhexanophenone

Base Information

• Chemical Name: 4'-isobutylhexanophenone
• CAS No.: 146922-67-0
• Molecular Formula: C₁₆H₂₄O
• Molecular Weight: 232.366
• Mol file: 146922-67-0.mol

Synonyms:4'-isobutylhexanophenone

Chemical Property of 4'-isobutylhexanophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4'-isobutylhexanophenone

There total 1 articles about 4'-isobutylhexanophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

1-phenyl-2-methylpropane (538-93-2) + Hexanoyl chloride (142-61-0) → 4'-isobutylhexanophenone (146922-67-0)

Guidance literature:

Hexanoyl chloride; With aluminium trichloride; In dichloromethane; at 0 ℃; for 0.5h;

1-phenyl-2-methylpropane; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1248/cpb.49.799

Reference yield: 88.0%

4'-isobutylhexanophenone (146922-67-0) → 1-(4-isobutylphenyl)hexan-1-ol (146922-68-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1248/cpb.49.799

Reference yield:

4'-isobutylhexanophenone (146922-67-0) → 1-(1-bromohexyl)-4-isobutylbenzene (146922-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaBH₄ / methanol / 1 h / 20 °C

2: 30.4 percent / CBr₄; PPh₃ / tetrahydrofuran / 5 h / 20 °C

With sodium tetrahydroborate; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.49.799

upstream raw materials:

1-phenyl-2-methylpropane

Hexanoyl chloride

Downstream raw materials:

1-(4-isobutylphenyl)hexan-1-ol

1-(1-bromohexyl)-4-isobutylbenzene

ethyl 4-[1-[4-[1-(4-isobutylphenyl)hexyloxy]benzoyl]indolizin-3-yl]butyrate

ethyl 4-[3-[4-[1-(4-isobutylphenyl)hexyloxy]benzoyl]indol-1-yl]butyrate

Refernces

• 1、 -. "INDOLE DERIVATIVES AND THEIR USE FOR TESTOSTERONE 5-ALPHA-REDUCTASE-MEDIATED DISEASES". . . Retrieved 2008/06/13.