Clovoxamine

Base Information

Chemical Name:Clovoxamine
CAS No.:54739-19-4
Molecular Formula:C14H21 Cl N2 O2
Molecular Weight:284.786
Hs Code.:
UNII:7I22J7RY2A
DSSTox Substance ID:DTXSID501023903
Wikipedia:Clovoxamine
NCI Thesaurus Code:C78003
Pharos Ligand ID:16KGG7K7ZP14
Metabolomics Workbench ID:55494
ChEMBL ID:CHEMBL4848304
Mol file:54739-19-4.mol

Synonyms:4'-chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime fumarate;clovoxamine

Suppliers and Price of Clovoxamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ClovoxamineFumarate
500mg
$ 155.00

American Custom Chemicals Corporation
CLOVOXAMINE 95.00%
5MG
$ 502.16

American Custom Chemicals Corporation
CLOVOXAMINE 95.00%
1MG
$ 315.00

Total 4 raw suppliers

Chemical Property of Clovoxamine

Chemical Property:

Vapor Pressure:3.2E-06mmHg at 25°C
Boiling Point:387.8°C at 760 mmHg
Flash Point:188.3°C
PSA：56.84000
Density:1.12g/cm³
LogP:3.53640
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:284.1291556
Heavy Atom Count:19
Complexity:254

Purity/Quality:

99% ^*data from raw suppliers

ClovoxamineFumarate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COCCCCC(=NOCCN)C1=CC=C(C=C1)Cl
Isomeric SMILES:COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)Cl

Technology Process of Clovoxamine

There total 4 articles about Clovoxamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 870-24-6
2-chloroethanamine hydrochloride

: (E)-N-[1-(4-chlorophenyl)-5-methoxypentylidene]hydroxylamine

: 54739-19-4
Clovoxamine

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 10 - 20 ℃;
DOI:10.1016/j.ejmech.2021.113533

Reference yield:

: 1346603-14-2
1-(4-chlorophenyl)-5-methoxypentan-1-one

: 54739-19-4
Clovoxamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 3 h / 20 °C

2: potassium hydroxide / N,N-dimethyl-formamide / 10 - 20 °C

With hydroxylamine hydrochloride; sodium acetate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113533

Reference yield:

: 623-03-0
4-Cyanochlorobenzene

: 54739-19-4
Clovoxamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; ethylene dibromide / diethyl ether / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 3 h / 20 °C

3.1: potassium hydroxide / N,N-dimethyl-formamide / 10 - 20 °C

With hydroxylamine hydrochloride; sodium acetate; magnesium; ethylene dibromide; potassium hydroxide; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113533