4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Base Information

Chemical Name:4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
CAS No.:1110770-25-6
Molecular Formula:C₁₆H₁₄BrF₃N₂O₂
Molecular Weight:403.199
Hs Code.:

Synonyms:4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

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Chemical Property of 4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Chemical Property:

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Technology Process of 4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

There total 4 articles about 4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1110771-68-0
ethyl 4-bromo-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

: 1003-03-8
Cyclopentamine

: 1110770-25-6
4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Guidance literature:: at 180 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1110770-25-6
4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / tetrahydrofuran; ethanol

2: hydroxylamine hydrochloride / ethanol / 85 °C

3: N-Bromosuccinimide / acetic acid / 100 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane

With N-Bromosuccinimide; hydroxylamine hydrochloride; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1016/j.bmcl.2010.12.092

Reference yield:

: 613240-18-9
5-(4-Trifluoromethyl-phenyl)-isoxazole-3-carboxylic Acid Ethyl Ester

: 1110770-25-6
4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / acetic acid / 100 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid;
DOI:10.1016/j.bmcl.2010.12.092