3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside

Base Information

• Chemical Name: 3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside
• CAS No.: 1228797-72-5
• Molecular Formula: C₅₅H₅₁N₅O₁₃
• Molecular Weight: 990.036
• Mol file: 1228797-72-5.mol

Synonyms:3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside

Chemical Property of 3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside

There total 2 articles about 3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

3-O-pivaloyl-N-ethoxycarbonylnormorphine (1228578-48-0) + 2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-α-D-xylopyranosyle trichloroacetimidate (1228797-71-4) → 3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside (1228797-72-5)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.ejmech.2011.05.076

Reference yield:

2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-α/β-D-xylopyranose → 3-O-pivaloyl-N-ethoxycarbonylnormorphin-6-yl2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-β-D-xylopyranoside (1228797-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / 20 °C

2: trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2011.05.076

upstream raw materials:

3-O-pivaloyl-N-ethoxycarbonylnormorphine

2,3,4-tri-O-benzoyl-5-C-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-α-D-xylopyranosyle trichloroacetimidate