3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

Base Information

Chemical Name:3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione
CAS No.:107583-28-8
Molecular Formula:C₂₂H₂₂N₄O₅
Molecular Weight:422.44
Hs Code.:

3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro<imidazolidine-4,4'(1'H)-quinazoline>-2,2',5(3'H)-trione

Synonyms:3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

Chemical Property:

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Technology Process of 3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

There total 7 articles about 3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107583-27-7
3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

: 74-88-4
methyl iodide

: 107583-28-8
3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h;
DOI:10.1021/jm00089a021

Reference yield:

: 42366-35-8,1769-41-1
hydroxyimino-N-phenylacetamide

: 107583-28-8
3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

Guidance literature:: Multi-step reaction with 6 steps

1: conc. H₂SO₄ / Heating

2: Et₃N / dimethylformamide / 1 h / 0 °C

3: 1.) Et₃N, 2.) 10percent aq. HCl / 1.) THF, RT, 3 h, 2.) THF, 80 deg C, 3 h

4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

5: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

6: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

With hydrogenchloride; sulfuric acid; sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00089a021

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 107583-28-8
3-acetyl-1-<(benzyloxy)methyl>-1',3'-dimethylspiro-2,2',5(3'H)-trione

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / dimethylformamide / 1 h / 0 °C

2: 1.) Et₃N, 2.) 10percent aq. HCl / 1.) THF, RT, 3 h, 2.) THF, 80 deg C, 3 h

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

5: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

With hydrogenchloride; sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00089a021