Technology Process of [(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester
There total 5 articles about [(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-{[(S)-1-(4-chloro-phenyl)-ethyl]-methoxycarbonyl-amino}-3-hydroxy-3-phenyl-pentanoic acid methyl ester; methyllithium;
In
tetrahydrofuran; diethyl ether;
at -75 - 70 ℃;
for 2.5h;
Inert atmosphere;
With
water; ammonium chloride;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / tetrahydrofuran / 20 °C
2.1: sodium carbonate / dichloromethane / 20 - 26 °C
3.1: diethylzinc / 1,2-dichloro-ethane / 0 °C / Inert atmosphere
3.2: 2.5 h / 0 - 20 °C / Inert atmosphere
3.3: Cooling with ice
4.1: diethyl ether; tetrahydrofuran / 2.5 h / -75 - 70 °C / Inert atmosphere
With
diethylzinc; sodium carbonate; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / tetrahydrofuran / 20 °C
2.1: sodium carbonate / dichloromethane / 20 - 26 °C
3.1: diethylzinc / 1,2-dichloro-ethane / 0 °C / Inert atmosphere
3.2: 2.5 h / 0 - 20 °C / Inert atmosphere
3.3: Cooling with ice
4.1: diethyl ether; tetrahydrofuran / 2.5 h / -75 - 70 °C / Inert atmosphere
With
diethylzinc; sodium carbonate; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane;