[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

Base Information

Chemical Name:[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester
CAS No.:1114563-51-7
Molecular Formula:C₂₃H₃₀ClNO₄
Molecular Weight:419.949
Hs Code.:

Synonyms:[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

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Chemical Property of [(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

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Technology Process of [(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

There total 5 articles about [(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1114563-48-2
5-{[(S)-1-(4-chloro-phenyl)-ethyl]-methoxycarbonyl-amino}-3-hydroxy-3-phenyl-pentanoic acid methyl ester

: 917-54-4
methyllithium

: 1114563-51-7
[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

Guidance literature:: 5-{[(S)-1-(4-chloro-phenyl)-ethyl]-methoxycarbonyl-amino}-3-hydroxy-3-phenyl-pentanoic acid methyl ester; methyllithium; In tetrahydrofuran; diethyl ether; at -75 - 70 ℃; for 2.5h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 4187-56-8
(S)-1-(p-chlorophenyl)ethylamine

: 1114563-51-7
[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: sodium carbonate / dichloromethane / 20 - 26 °C

3.1: diethylzinc / 1,2-dichloro-ethane / 0 °C / Inert atmosphere

3.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.3: Cooling with ice

4.1: diethyl ether; tetrahydrofuran / 2.5 h / -75 - 70 °C / Inert atmosphere

With diethylzinc; sodium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1114563-51-7
[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: sodium carbonate / dichloromethane / 20 - 26 °C

3.1: diethylzinc / 1,2-dichloro-ethane / 0 °C / Inert atmosphere

3.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.3: Cooling with ice

4.1: diethyl ether; tetrahydrofuran / 2.5 h / -75 - 70 °C / Inert atmosphere

With diethylzinc; sodium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane;