3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

Base Information

Chemical Name:3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one
CAS No.:1114091-17-6
Molecular Formula:C₂₂H₂₆ClNO₃
Molecular Weight:387.906
Hs Code.:

Synonyms:3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

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Chemical Property of 3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

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Technology Process of 3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

There total 6 articles about 3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1114563-51-7
[(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester

: 1114563-54-0
3-[(S)-1-(4-chloro-phenyl)ethyl]-(R)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

: 1114091-17-6
3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

Guidance literature:: [(S)-1-(4-chloro-phenyl)-ethyl]-(3,5-dihydroxy-5-methyl-3-phenyl-hexyl)-carbamic acid methyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; for 2.5h; Inert atmosphere; Reflux;

With water; ammonium chloride; In tetrahydrofuran; mineral oil;

Reference yield:

: 4187-56-8
(S)-1-(p-chlorophenyl)ethylamine

: 1114563-54-0
3-[(S)-1-(4-chloro-phenyl)ethyl]-(R)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

: 1114091-17-6
3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: sodium carbonate / dichloromethane / 20 - 26 °C

3.1: diethylzinc / 1,2-dichloro-ethane / 0 °C / Inert atmosphere

3.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.3: Cooling with ice

4.1: diethyl ether; tetrahydrofuran / 2.5 h / -75 - 70 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / Inert atmosphere; Reflux

With diethylzinc; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; mineral oil;

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1114563-54-0
3-[(S)-1-(4-chloro-phenyl)ethyl]-(R)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

: 1114091-17-6
3-[(S)-1-(4-chloro-phenyl)ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: sodium carbonate / dichloromethane / 20 - 26 °C

3.1: diethylzinc / 1,2-dichloro-ethane / 0 °C / Inert atmosphere

3.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.3: Cooling with ice

4.1: diethyl ether; tetrahydrofuran / 2.5 h / -75 - 70 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / Inert atmosphere; Reflux

With diethylzinc; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; mineral oil;