ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

Base Information

Chemical Name:ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate
CAS No.:1428929-04-7
Molecular Formula:C₂₂H₂₂F₃NO₃
Molecular Weight:405.417
Hs Code.:

Synonyms:ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

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Chemical Property of ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

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Technology Process of ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

There total 6 articles about ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1020325-38-5
2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1428929-04-7
ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

Guidance literature:: 2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h;

ethyl 4-oxocyclohexane-1-carboxylate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 18h;

Reference yield:

: 1020333-02-1
3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde

: 1428929-04-7
ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

2.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

3.1: 18 h / 150 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 0 - 20 °C

4.2: 18 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; mineral oil; 4.1: |Wittig-Horner Reaction / 4.2: |Wittig-Horner Reaction;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1428929-04-7
ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

4.1: 18 h / 150 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 18 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 5.1: |Wittig-Horner Reaction / 5.2: |Wittig-Horner Reaction;