4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

Base Information

Chemical Name:4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid
CAS No.:1428929-05-8
Molecular Formula:C₂₀H₁₈F₃NO₃
Molecular Weight:377.363
Hs Code.:

Synonyms:4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

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Chemical Property of 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

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Technology Process of 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

There total 7 articles about 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1428929-04-7
ethyl 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylate

: 1428929-05-8
4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 20h;

Reference yield:

: 1020333-02-1
3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde

: 1428929-05-8
4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

2.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

3.1: 18 h / 150 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 0 - 20 °C

4.2: 18 h / 0 - 20 °C

5.1: sodium hydroxide / ethanol; water / 20 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; mineral oil; 4.1: |Wittig-Horner Reaction / 4.2: |Wittig-Horner Reaction;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1428929-05-8
4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexane carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

4.1: 18 h / 150 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 18 h / 0 - 20 °C

6.1: sodium hydroxide / ethanol; water / 20 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 5.1: |Wittig-Horner Reaction / 5.2: |Wittig-Horner Reaction;