(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

Base Information

Chemical Name:(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate
CAS No.:84520-89-8
Molecular Formula:C₃₃H₃₆N₂O₇
Molecular Weight:572.658
Hs Code.:

Synonyms:(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

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Chemical Property of (4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

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Technology Process of (4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

There total 7 articles about (4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 118-58-1
benzyl salicylate

: 84520-87-6
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester

: 84520-89-8
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00358a017

Reference yield:

: 84520-72-9
(4S)-1-benzoyl-1-azido-L-proline methyl ester

: 84520-89-8
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

Guidance literature:: Multi-step reaction with 5 steps

1: concd. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

2: dioxane; dimethylformamide / 48 h / 50 °C

3: 75 percent / NaBH₃CN / acetonitrile / 0.25 h / Ambient temperature

4: 62 percent / NaOH / methanol / 3 h / Ambient temperature

5: 66 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; hydrogen; sodium cyanoborohydride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00358a017

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 84520-89-8
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl ester 2-ester with benzyl salicylate

Guidance literature:: Multi-step reaction with 6 steps

1: DCC / 48 h

2: concd. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

3: dioxane; dimethylformamide / 48 h / 50 °C

4: 75 percent / NaBH₃CN / acetonitrile / 0.25 h / Ambient temperature

5: 62 percent / NaOH / methanol / 3 h / Ambient temperature

6: 66 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; hydrogen; sodium cyanoborohydride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00358a017