118-58-1Relevant articles and documents
Esterification of salicylic acid using Br?nsted acidic ionic liquid based on Keggin heteropoly acid
Bamoharram, Fatemeh F.,Heravi, Majid M.,Ebrahimi, Javad,Tavakoli-Hoseini, Nilofar
, p. 36 - 42 (2014)
For the first time, a newwater stable Br?nsted acidic ionic liquid based on Keggin heteroployacid (HPA) was used as environmentally benign catalytic medium in the esterfication of salicylic acid with aliphatic alcohols, CnH2n+1OH (n = 1-5) and benzylic alcohols, RC6H4CH2OH (R = H, NO2, OCH3). This ionic liquid (IL) afforded excellent yield in both thermal conditions and microwave irradiation. Maximum yields were observed under microwave irradiation. Different reaction runs were conducted by varying the reaction parameters such as molar ratio of reactants, weight of the IL, and reaction period in order to optimize the reaction. The IL was easily recovered and reused many times. No significant loss in catalytic activity was observed on recycling.
A facile and efficient nucleophilic displacement reaction at room temperature in ionic liquids
Judeh, Zaher M.A,Shen, Hao-Yu,Chi, Bun Ching,Feng, Li-Chun,Selvasothi, Selvaratnam
, p. 9381 - 9384 (2002)
We have investigated the use of room temperature ionic liquids as catalytic and environmentally benign solvents for the facile homogenous synthesis of benzyl salicylate by the nucleophilic displacement reaction between sodium salicylate and benzyl chloride. The reaction was found to proceed under relatively mild conditions with excellent conversion (up to 96%) without the use of PTCs. The ionic liquids were recycled and reused. The effect of temperature was also investigated. No by-products were observed after 1H NMR and GC analysis.
Homogeneous system for the synthesis of benzyl salicylate
Sivakumar, Sri,Pangarkar, Vishwas G.,Sawant, Sudhir B.
, p. 149 - 151 (2002)
Synthesis of benzyl salicylate from sodium salicylate and benzyl chloride in the absence of a PTC and with dimethyl formamide as a solvent has been reported. Almost complete conversion of benzyl chloride can be achieved in 1.5 h at 110°C. The batch time and the reaction temperature are considerably less than that for the commercial process using a PTC. Kinetics of the reaction have been investigated.
Benzoic acid tryptamine derivative as well as preparation method and application thereof
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Paragraph 0033, (2021/10/30)
The invention provides a benzoic acid tryptamine derivative as well as preparation and application thereof. The benzoic acid tryptamine derivative uses a salicylic acid compound as a starting raw material and is protected by benzyl. The method comprises the following four-step reaction synthesis of carbamylation, deprotection and condensation. The benzoic acid tryptamine derivative prepared by the invention has dual inhibition effects of acetylcholinesterase and butyrylcholine esterase. Moreover, as a hybrid reversible inhibitor, the content and expression AChE of cells and animals can be reduced. , Good anti-neuroinflammation activity can be achieved, A β aggregation can be inhibited, BACE-1 expression is reduced. The learning memory and anti-depression ability of AD model mice can be remarkably improved, no obvious toxicity exists on cells and animals, and the drug has good pharmacokinetic performance and blood brain barrier permeability, and can be applied to preparation of's disease treatment drugs.
Amide/Iminium Zwitterionic Catalysts for (Trans)esterification: Application in Biodiesel Synthesis
Lam, Ying-Pong,Ng, Wing-Hin,Tan, Fei,Tse, Ying-Lung Steve,Wang, Xinyan,Yeung, Ying-Yeung
, p. 8083 - 8092 (2019/08/26)
A class of zwitterionic organocatalysts based on an amide anion/iminium cation charge pair has been developed. The zwitterions are easily prepared by reacting aziridines with aminopyridines. They are catalytically applicable to transesterifications and dehydrative esterifications. Mechanistic studies reveal that the amide anion and iminium cation work synergistically in activating the reaction partners, with the iminium cationic moiety interacting with the carbonyl substrates through nonclassical hydrogen bonding. The reaction can be applied to large-scale synthesis of biodiesel under mild conditions.
