{3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol

Base Information

• Chemical Name: {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol
• CAS No.: 692204-93-6
• Molecular Formula: C₅₇H₅₇BrClIO₈
• Molecular Weight: 1112.34
• Mol file: 692204-93-6.mol

Synonyms:{3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol

Chemical Property of {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol

There total 16 articles about {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-Bromo-benzyloxy)-3-bromomethyl-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzene (692204-62-9) + 3-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-5-hydroxymethyl-2-iodo-phenol → {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol (692204-93-6)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 12h; Heating;

DOI:10.1021/jo049878p

Reference yield:

ethyl 3,5-dihydroxybenzoate (4142-98-7) → {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol (692204-93-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 24 percent / N-iodosuccinimide / acetonitrile / 8 h

2: 31 percent / pyridine / CH₂Cl₂ / 6 h

3: potassium carbonate; 18-crown-6 / tetrahydrofuran / 12 h / Heating

4: borane-dimethyl sulfide complex / tetrahydrofuran / 8 h / Heating

5: 90 percent / potassium carbonate; 18-crown-6 / acetone / 12 h / Heating

With pyridine; N-iodo-succinimide; 18-crown-6 ether; dimethylsulfide borane complex; potassium carbonate; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

DOI:10.1021/jo049878p

Reference yield:

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) → {3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-4-iodo-phenyl}-methanol (692204-93-6)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium carbonate; 18-crown-6 / tetrahydrofuran / 8 h / Heating

2: 1.96 g / sodium hydride / tetrahydrofuran / 1 h / 20 °C

3: 90 percent / borane-dimethyl sulfide complex / tetrahydrofuran / 8 h / Heating

4: 92 percent / triphenylphosphine; N-bromosuccinimide / tetrahydrofuran / 20 °C

5: potassium carbonate; 18-crown-6 / tetrahydrofuran / 12 h / Heating

6: borane-dimethyl sulfide complex / tetrahydrofuran / 8 h / Heating

7: 90 percent / potassium carbonate; 18-crown-6 / acetone / 12 h / Heating

With N-Bromosuccinimide; 18-crown-6 ether; dimethylsulfide borane complex; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetone;

DOI:10.1021/jo049878p

upstream raw materials:

1-(4-Bromo-benzyloxy)-3-bromomethyl-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzene

ethyl 3,5-dihydroxybenzoate

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

1-bromomethyl-4-bromobenzene

Downstream raw materials:

1-{3-(4-Bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxy}-5-bromomethyl-3-[3-(4-tert-butyl-benzyloxy)-5-(3-chloro-benzyloxymethyl)-benzyloxy]-2-iodo-benzene