(2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide

Base Information

• Chemical Name: (2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide
• CAS No.: 190909-11-6
• Molecular Formula: C₃₀H₄₃N₅O₄
• Molecular Weight: 537.703

Synonyms:(2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide

Chemical Property of (2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide

There total 6 articles about (2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

O-benzylhydoxylamine hydrochloride (2687-43-6) + (R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-(4-methyl-piperazin-1-ylmethyl)-hexanoic acid → (2R,3R)-N4-Benzyloxy-2-isobutyl-N1-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide (190909-11-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

(2R)-2-bromo-4-methylpentanoic acid t-butyl ester (130464-88-9) → (2R,3R)-N4-Benzyloxy-2-isobutyl-N1-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide (190909-11-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 49.6 percent / t-BuOK / dimethylformamide / 96 h / 0 - 5 °C

2: 61.5 percent / 95percent aq. CF₃COOH / Ambient temperature

3: 95 percent / HOBT, 4-aminopyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

4: 1.) ammonium formate, 2.) piperidine / 1.) 10percent Pd/C

5: 90 percent / NaHCO₃ / dimethylformamide / Ambient temperature

6: 55 percent / 1 h / 60 °C

7: H₂ / 10percent Pd/C / methanol

8: 71.5 percent / HOBT, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide, N-methylmorpholine / dimethylformamide; CH₂Cl₂ / Ambient temperature

With piperidine; 4-methyl-morpholine; 4-aminopyridine; potassium tert-butylate; hydrogen; ammonium formate; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

benzyl 2<(benzyloxy)carbonyl>-3(R)-(hydroxycarbonyl)-5-methylhexanoate (155947-71-0) → (2R,3R)-N4-Benzyloxy-2-isobutyl-N1-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide (190909-11-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / HOBT, 4-aminopyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

2: 1.) ammonium formate, 2.) piperidine / 1.) 10percent Pd/C

3: 90 percent / NaHCO₃ / dimethylformamide / Ambient temperature

4: 55 percent / 1 h / 60 °C

5: H₂ / 10percent Pd/C / methanol

6: 71.5 percent / HOBT, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide, N-methylmorpholine / dimethylformamide; CH₂Cl₂ / Ambient temperature

With piperidine; 4-methyl-morpholine; 4-aminopyridine; hydrogen; ammonium formate; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00028-X

upstream raw materials:

O-benzylhydoxylamine hydrochloride

(2R)-2-bromo-4-methylpentanoic acid t-butyl ester

benzyl 2<(benzyloxy)carbonyl>-3(R)-(hydroxycarbonyl)-5-methylhexanoate

2-Benzyloxycarbonyl-3R-isobutyl-succinic acid 4-tert-butyl ester 1-benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 190909-11-6 (2R,3R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-3-(4-methyl-piperazin-1-ylmethyl)-succinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send