lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

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Chemical Name:lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate
CAS No.:1620678-53-6
Molecular Formula:C₂₁H₂₀N₅O₃*Li
Molecular Weight:397.362
Hs Code.:

Synonyms:lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

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Chemical Property of lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

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Technology Process of lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

There total 11 articles about lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1620678-54-7
methyl 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

: 1620678-53-6
lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 45 ℃; for 15h;

Reference yield:

: 1620675-70-8
(6R,8aS)-6-(8-chloroimidazo[1,5-a]pyrazin-3-yl)hexahydroindolizin-3(2H)-one

: 1620678-53-6
lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

2: ammonium hydroxide / methanol / 24 h / 120 °C / Sealed tube

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 90 °C

4: water; lithium hydroxide / methanol; tetrahydrofuran / 15 h / 45 °C

With ammonium hydroxide; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;

Reference yield:

: 1620675-71-9
(6R,8aS)-6-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)hexahydroindolizin-3(2H)-one

: 1620678-53-6
lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol / 24 h / 120 °C / Sealed tube

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 90 °C

3: water; lithium hydroxide / methanol; tetrahydrofuran / 15 h / 45 °C

With ammonium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water;