4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

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Chemical Name:4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide
CAS No.:1620674-89-6
Molecular Formula:C₂₅H₂₃F₃N₈O₂
Molecular Weight:524.505
Hs Code.:

Synonyms:4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

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Chemical Property of 4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

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Technology Process of 4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

There total 12 articles about 4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.67%

: 852443-61-9
5-amino-3-(trifluoromethyl)-1H-pyrazole

: 1620678-53-6
lithium 4-(8-amino-3-((6R,8aS)-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)benzoate

: 1620674-89-6
4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield:

: 1620675-71-9
(6R,8aS)-6-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)hexahydroindolizin-3(2H)-one

: 1620674-89-6
4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / methanol / 24 h / 120 °C / Sealed tube

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 90 °C

3: water; lithium hydroxide / methanol; tetrahydrofuran / 15 h / 45 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

With ammonium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1620675-62-8
(6R,8aS)-6-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)hexahydroindolizin-3(2H)-one

: 1620674-89-6
4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[3-(trifluoromethyl)-1H-pyrazol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 90 °C

2: water; lithium hydroxide / methanol; tetrahydrofuran / 15 h / 45 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;