2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346447-92-4
Molecular Formula:C₂₄H₂₆ClN₇O₂
Molecular Weight:479.969
Hs Code.:

Synonyms:2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

There total 6 articles about 2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1413945-87-5
dimethylaminoacetaldehyde-hydrogen sulphite adduct

: 1346447-91-3
diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

: 1346447-92-4
2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate; With water; lithium chloride; potassium hydroxide; In ethanol; at 20 - 50 ℃; for 0.583333h;

dimethylaminoacetaldehyde-hydrogen sulphite adduct; In ethanol; water; at 20 ℃; for 3h;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346447-92-4
2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,4-dioxane / 0.33 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

4.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 0.5 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.17 h / 20 °C

5.2: 14 h / 20 °C

6.1: potassium hydroxide; water; lithium chloride / ethanol / 0.58 h / 20 - 50 °C

6.2: 3 h / 20 °C

With water; hydrogen; potassium carbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; lithium chloride; potassium hydroxide; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1346447-92-4
2-((5-chloro-2-((3-(4-(dimethylamino)but-2-enamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

2.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 0.5 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.17 h / 20 °C

3.2: 14 h / 20 °C

4.1: potassium hydroxide; water; lithium chloride / ethanol / 0.58 h / 20 - 50 °C

4.2: 3 h / 20 °C

With water; hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; lithium chloride; potassium hydroxide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; isopropyl alcohol;