diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

Base Information

Chemical Name:diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate
CAS No.:1346447-91-3
Molecular Formula:C₂₄H₂₈ClN₆O₅P
Molecular Weight:546.95
Hs Code.:

Synonyms:diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

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Chemical Property of diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

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Technology Process of diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

There total 5 articles about diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 3095-95-2
diethylphosphonoacetic acid

: 1346447-71-9
2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

: 1346447-91-3
diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

Guidance literature:: diethylphosphonoacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.166667h;

2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide; In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346447-91-3
diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / 0.33 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

4.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 0.5 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.17 h / 20 °C

5.2: 14 h / 20 °C

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1346447-91-3
diethyl (2-((3-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)amino)-2-oxoethyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

2.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 0.5 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.17 h / 20 °C

3.2: 14 h / 20 °C

With hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; isopropyl alcohol;