Technology Process of 5,7-Bis-benzyloxy-6-fluoro-1H-indole-2-carbaldehyde
There total 13 articles about 5,7-Bis-benzyloxy-6-fluoro-1H-indole-2-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide;
In
dichloromethane;
at 25 ℃;
for 1.5h;
DOI:10.1248/cpb.38.2939
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 100 percent / imidazole / tetrahydrofuran / 25 °C
3: 100 percent / imidazole / tetrahydrofuran / 25 °C
5: 100 percent / imidazole / tetrahydrofuran / 25 °C
6: 100 percent / Dowex50-X8 resin (H+ form), MeOH / 5 h / 25 °C
7: 73 percent / pyridinium chlorochromate,NaOAc / CH2Cl2 / 1.2 h / 25 °C
8: 94 percent / KF / dimethylformamide / 3 h / 25 °C
9: 74 percent / NaOMe / methanol; tetrahydrofuran / 1.) -10 degC, 3 h, 2.) -10 -> 25 degC
10: 94 percent / xylene / 3 h / Heating
11: LiAlH4 / tetrahydrofuran / 1 h / 25 °C
12: 85 percent / MnO2 / CH2Cl2 / 1.5 h / 25 °C
With
1H-imidazole; methanol; manganese(IV) oxide; potassium fluoride; lithium aluminium tetrahydride; Dowex50-X8 resin (H+ form); sodium methylate; sodium acetate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; xylene;
DOI:10.1248/cpb.38.2939
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / KF / dimethylformamide / 3 h / 25 °C
2: 74 percent / NaOMe / methanol; tetrahydrofuran / 1.) -10 degC, 3 h, 2.) -10 -> 25 degC
3: 94 percent / xylene / 3 h / Heating
4: LiAlH4 / tetrahydrofuran / 1 h / 25 °C
5: 85 percent / MnO2 / CH2Cl2 / 1.5 h / 25 °C
With
manganese(IV) oxide; potassium fluoride; lithium aluminium tetrahydride; sodium methylate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; xylene;
DOI:10.1248/cpb.38.2939
