(R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

Base Information

Chemical Name:(R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate
CAS No.:114375-72-3
Molecular Formula:C₄₇H₆₆O₆
Molecular Weight:727.037
Hs Code.:

Synonyms:(R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

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Chemical Property of (R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

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Technology Process of (R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

There total 6 articles about (R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 95061-47-5
(R)-2-acetoxy-1,1,2-triphenylethanol

: (S,Z)-3-<(tetrahydro-2H-pyran-2-yl)oxy>-11-icosenal

: 114375-72-3
(R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; diethyl ether; at -118 ℃; for 1h;
DOI:10.1002/hlca.19870700522

Reference yield:

: 2423-10-1
Oleic aldehyde

: 114375-72-3
(R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / BuLi / tetrahydrofuran; diethyl ether / 1 h / -112 °C

2: methanol / 1 h / Ambient temperature

3: 74.5 percent / TsOH / CH₂Cl₂ / 0.75 h / 0 °C

4: 91 percent / DIBAH / CH₂Cl₂; toluene / 0.58 h / -70 °C

5: 77 percent / BuLi / tetrahydrofuran; diethyl ether / 1 h / -118 °C

With n-butyllithium; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1002/hlca.19870700522

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 114375-72-3
(R)-2-hydroxy-1,2,2-triphenylethyl (3S,5S,Z)-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>-13-docosenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 74.5 percent / TsOH / CH₂Cl₂ / 0.75 h / 0 °C

2: 91 percent / DIBAH / CH₂Cl₂; toluene / 0.58 h / -70 °C

3: 77 percent / BuLi / tetrahydrofuran; diethyl ether / 1 h / -118 °C

With n-butyllithium; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1002/hlca.19870700522