Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

Base Information

Chemical Name:Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine
CAS No.:1353562-62-5
Molecular Formula:C₄₆H₆₇N₃O₆
Molecular Weight:758.054
Hs Code.:

Synonyms:Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

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Chemical Property of Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

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Technology Process of Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

There total 7 articles about Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1353562-61-4
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

: 1353562-62-5
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

Guidance literature:: Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester; With sodium hydroxide; In methanol; at 0 - 20 ℃; for 4h;

With hydrogenchloride; In methanol; water; pH=2 - 3;
DOI:10.1016/j.tetlet.2011.11.057

Reference yield:

: 124-09-4
1,6-Hexanediamine

: 1353562-62-5
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / 2 h / 0 - 20 °C

2.1: sodium tetrahydroborate / methanol / 1.5 h / Reflux

2.2: 0 °C

3.1: sodium carbonate; sodium iodide / butan-1-ol / 24 h / 0 °C / Reflux; Inert atmosphere

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux; Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 40 °C / Inert atmosphere

5.2: 74 h / 50 °C / Inert atmosphere

6.1: sodium hydroxide / methanol / 4 h / 0 - 20 °C

6.2: pH 2 - 3

With sodium tetrahydroborate; oxalyl dichloride; sodium carbonate; caesium carbonate; N,N-dimethyl-formamide; sodium iodide; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.tetlet.2011.11.057

Reference yield:

: 1353562-60-3
N,N'-dibenzyl-1,20-dichloro-7,14-hexanediazaeicosane

: 1353562-62-5
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 40 °C / Inert atmosphere

1.2: 74 h / 50 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 4 h / 0 - 20 °C

2.2: pH 2 - 3

With caesium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.11.057