Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

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Chemical Name:Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester
CAS No.:1353562-61-4
Molecular Formula:C₄₇H₆₉N₃O₆
Molecular Weight:772.081
Hs Code.:

Synonyms:Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

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Chemical Property of Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

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Technology Process of Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

There total 6 articles about Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1353562-60-3
N,N'-dibenzyl-1,20-dichloro-7,14-hexanediazaeicosane

: 37169-36-1
methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

: 1353562-61-4
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

Guidance literature:: methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate; With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 0.5h; Inert atmosphere;

N,N'-dibenzyl-1,20-dichloro-7,14-hexanediazaeicosane; With caesium bromide; In N,N-dimethyl-formamide; at 50 ℃; for 74h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.11.057

Reference yield:

: 124-09-4
1,6-Hexanediamine

: 1353562-61-4
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water / 2 h / 0 - 20 °C

2.1: sodium tetrahydroborate / methanol / 1.5 h / Reflux

2.2: 0 °C

3.1: sodium carbonate; sodium iodide / butan-1-ol / 24 h / 0 °C / Reflux; Inert atmosphere

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux; Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 40 °C / Inert atmosphere

5.2: 74 h / 50 °C / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; sodium carbonate; caesium carbonate; N,N-dimethyl-formamide; sodium iodide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.tetlet.2011.11.057

Reference yield:

: 1353562-59-0
N,N'-dibenzyl-7,14-hexanediazaeicosane-1,20-diol

: 1353562-61-4
Nα-tert-butyloxycarbonyl-3-(3,4-(N-dibenzyl-11,18-diaza-1,4-dioxa-cyclotetracosane)-phenyl)-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux; Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 40 °C / Inert atmosphere

2.2: 74 h / 50 °C / Inert atmosphere

With oxalyl dichloride; caesium carbonate; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.11.057