5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

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Chemical Name:5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one
CAS No.:900509-77-5
Molecular Formula:C₂₅H₃₄O₈
Molecular Weight:462.54
Hs Code.:

Synonyms:5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

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Chemical Property of 5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

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Technology Process of 5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

There total 12 articles about 5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 900509-76-4
5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-ol

: 900509-77-5
5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/j.tet.2006.04.026

Reference yield:

: 90-05-1
2-methoxy-phenol

: 900509-77-5
5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran / 2 h / -15 - 20 °C

2.2: 14 percent / I₂ / tetrahydrofuran / -45 - 20 °C

3.1: 99 percent / Ph₃P; Et₃N; CuI / PdCl₂(PPh₃)2 / 80 °C

4.1: 72 percent / NaOH / toluene / 3.5 h / Heating

5.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

5.2: 54 percent / tetrahydrofuran; hexane / -78 - 20 °C

6.1: 83 percent / H₂; K₂CO₃ / Pd/C / ethyl acetate / 2 h / 20 °C

7.1: 99 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

With sodium hydroxide; copper(l) iodide; n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; toluene; 3.1: Sonogashira coupling;
DOI:10.1016/j.tet.2006.04.026

Reference yield:

: 68945-13-1
1-allyl-3-methoxy-2-((2-methoxyethoxy)methoxy)benzene

: 900509-77-5
5-[3-methoxy-2-((2-methoxyethoxy)methoxy)phenyl]-1-[3-methoxy-2-(methoxymethoxy)phenyl]-pentan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃*SMe₂ / tetrahydrofuran / 0 - 20 °C

1.2: 55 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran; methanol / 20 °C

2.1: 70 percent / 4 Angstroem molecular sieves; tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide / CH₂Cl₂ / 1 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

3.2: 54 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: 83 percent / H₂; K₂CO₃ / Pd/C / ethyl acetate / 2 h / 20 °C

5.1: 99 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

With n-butyllithium; tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4 A molecular sieve; hydrogen; potassium carbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2006.04.026