8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

Base Information

Chemical Name:8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)
CAS No.:476468-49-2
Molecular Formula:C₄₀H₄₃N₅O₉P₂
Molecular Weight:799.757
Hs Code.:

Synonyms:8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

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Chemical Property of 8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

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Technology Process of 8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

There total 8 articles about 8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 476468-48-1
8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine

: 476468-49-2
8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -40 - 20 ℃;
DOI:10.1021/jo026268l

Reference yield:

: 55457-17-5
2-methylpyrazolo<1,5-a>-s-triazin-4-one

: 476468-49-2
8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / N,N-dimethylaniline; POCl₃ / 2 h / Heating

2: 1.46 g / CH₂Cl₂ / 0 - 20 °C

3: 87 percent / N-iodosuccinimide / CHCl₃ / 0.5 h / Heating

4: 75 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾; Ph₃As; (n-Bu)3N / acetonitrile / 18 h / 60 °C

5: 92 percent / sodium triacetoxyborohydride / acetonitrile / 0.33 h / 20 °C

6: 73 percent / ethanol / 12 h / 100 °C

7: 66 percent / t-BuOK / tetrahydrofuran / -40 - 20 °C

With N-iodo-succinimide; tributyl-amine; triphenyl-arsane; potassium tert-butylate; sodium tris(acetoxy)borohydride; N,N-dimethyl-aniline; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jo026268l

Reference yield:

: 96761-00-1
1,4-anhydro-2-deoxy-D-erythro-pent-1-enitol

: 476468-49-2
8-(2'-deoxy-β-D-ribofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-bis(dibenzyl phosphate)

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾; Ph₃As; (n-Bu)3N / acetonitrile / 18 h / 60 °C

2: 92 percent / sodium triacetoxyborohydride / acetonitrile / 0.33 h / 20 °C

3: 73 percent / ethanol / 12 h / 100 °C

4: 66 percent / t-BuOK / tetrahydrofuran / -40 - 20 °C

With tributyl-amine; triphenyl-arsane; potassium tert-butylate; sodium tris(acetoxy)borohydride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jo026268l