5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

Base Information

Chemical Name:5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde
CAS No.:240122-01-4
Molecular Formula:C₂₀H₂₈O₅Si
Molecular Weight:376.525
Hs Code.:

Synonyms:5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

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Chemical Property of 5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

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Technology Process of 5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

There total 6 articles about 5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 240122-00-3
5-(4,6-dimethoxy-2-hydroxymethylphenyl)-furan-2-yl-aldehyde

: 240122-01-4
5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ol0000253

Reference yield:

: 2-(tributylstannyl)-5-(1,3-dioxolan-2-yl)-furan

: 240122-01-4
5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; Pd₂(dba)3*CHCl₃ / toluene / Heating

2: aq. HCl / acetone / 20 °C

3: 73 percent / imidazole; DMAP / dimethylformamide / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; In N,N-dimethyl-formamide; acetone; toluene; 1: Phenylation / 2: Hydrolysis / 3: silylation;
DOI:10.1021/ol0000253

Reference yield:

: 74726-76-4
2-bromo-3,5-dimethoxybenzyl alcohol

: 240122-01-4
5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; Pd₂(dba)3*CHCl₃ / toluene / Heating

2: aq. HCl / acetone / 20 °C

3: 73 percent / imidazole; DMAP / dimethylformamide / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; In N,N-dimethyl-formamide; acetone; toluene; 1: Phenylation / 2: Hydrolysis / 3: silylation;
DOI:10.1021/ol0000253