(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

Base Information

Chemical Name:(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester
CAS No.:99300-11-5
Molecular Formula:C₃₆H₅₂O₁₃
Molecular Weight:692.801
Hs Code.:

(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

Synonyms:(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

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Chemical Property of (2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

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Technology Process of (2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

There total 5 articles about (2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 108-24-7
acetic anhydride

: 99285-18-4
(2R,3S,4S)-3-Acetoxy-4-((2R,3R,5R,6R)-6-{(S)-1-[(4S,5S)-5-(1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-ethyl}-3-benzyloxy-6-hydroxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-2-methyl-pentanoic acid methyl ester

: 99300-11-5
(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

Guidance literature:: With triethylamine; In various solvent(s); at 25 ℃; for 20h;
DOI:10.1139/v85-470

Reference yield:

: 99285-06-0,99340-62-2
(2R,3S,4S)-4-((2R,3R,5R,6R,8S,9R,10S,11S)-3-Benzyloxy-8-ethyl-9,10-dihydroxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-3-hydroxy-2-methyl-pentanoic acid methyl ester

: 99300-11-5
(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 98 percent / imidazole / xylene / 0.67 h / 95 - 100 °C

3: 81 percent / p-toluenesulfonic acid / acetic acid / 0.5 h / 60 - 70 °C

4: 68 percent / 30percent aq. HCl / acetone / 24 h / 25 °C

5: 74 percent / triethylamine / various solvent(s) / 20 h / 25 °C

With pyridine; 1H-imidazole; hydrogenchloride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; acetic acid; acetone; xylene;
DOI:10.1139/v85-470

Reference yield:

: 99285-11-7,99340-64-4
C₃₀H₄₄O₉

: 99300-11-5
(2R,3S,4S,5R,6R,8R,10R)-3,5-Diacetoxy-10-[(4R,5R)-5-((R)-1-acetoxy-propyl)-5-methyl-2-oxo-[1,3]dioxolan-4-yl]-6-benzyloxy-2,4,6,8-tetramethyl-9-oxo-undecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / p-toluenesulfonic acid / acetic acid / 0.5 h / 60 - 70 °C

2: 68 percent / 30percent aq. HCl / acetone / 24 h / 25 °C

3: 74 percent / triethylamine / various solvent(s) / 20 h / 25 °C

With hydrogenchloride; toluene-4-sulfonic acid; triethylamine; In acetic acid; acetone;
DOI:10.1139/v85-470