3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

Base Information

Chemical Name:3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid
CAS No.:1314258-64-4
Molecular Formula:C₂₁H₁₅N₃O₂
Molecular Weight:341.369
Hs Code.:

Synonyms:3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

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Chemical Property of 3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

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Technology Process of 3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

There total 5 articles about 3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1314264-05-5
1-phenyl-3-(3-bromophenyl)-4-(pyridin-4-yl)-1H-pyrazole

: 13939-06-5,199620-15-0
molybdenum hexacarbonyl

: 1314258-64-4
3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

Guidance literature:: 1-phenyl-3-(3-bromophenyl)-4-(pyridin-4-yl)-1H-pyrazole; molybdenum hexacarbonyl; With sodium carbonate; Herrmann's palladacycle; In water; at 150 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

With potassium hydroxide; In water;

With hydrogenchloride; In water;

Reference yield:

: 108-89-4
picoline

: 1314258-64-4
3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C

2.1: 0.5 h / 100 °C

2.2: 1 h / 80 °C

3.1: copper diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

4.1: sodium carbonate / Herrmann's palladacycle / water / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere

With copper diacetate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; Herrmann's palladacycle; In tetrahydrofuran; water; dimethyl sulfoxide;

Reference yield:

: 618-89-3
methyl 3-bromobenzoate

: 1314258-64-4
3-[1-phenyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C

2.1: 0.5 h / 100 °C

2.2: 1 h / 80 °C

3.1: copper diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

4.1: sodium carbonate / Herrmann's palladacycle / water / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere

With copper diacetate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; Herrmann's palladacycle; In tetrahydrofuran; water; dimethyl sulfoxide;