3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

Base Information

Chemical Name:3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid
CAS No.:1612884-37-3
Molecular Formula:C₁₇H₂₂O₇
Molecular Weight:338.357
Hs Code.:

Synonyms:3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

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Chemical Property of 3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

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Technology Process of 3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

There total 6 articles about 3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 5961-83-1
3-(2-carboxyethoxy)propionic acid

: 192803-37-5
3-tert-butyl-2,5-dihydroxybenzaldehyde

: 1612884-37-3
3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.043

Reference yield:

: 1948-33-0
tert-butylhydroquinone

: 1612884-37-3
3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole; dmap / dichloromethane / 18 h / 0 - 4 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine; tin(IV) chloride / toluene / 1 h / 0 °C / Inert atmosphere

2.2: 24 h / 90 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol; water / 5 h / 20 °C / Inert atmosphere

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; dmap; tin(IV) chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2014.03.043

Reference yield:

: 246509-53-5
2-hydroxy-5-pivaloyloxy-3-tert-butylbenzaldehyde

: 1612884-37-3
3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 5 h / 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.03.043