192803-37-5

Basic information

• Product Name: 3-tert-butyl-2,5-dihydroxy-benzaldehyde
• Synonyms: 3-tert-Butyl-2,5-dihydroxybenzaldehyde; benzaldehyde, 3-(1,1-dimethylethyl)-2,5-dihydroxy-
• CAS NO: 192803-37-5
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol File: 192803-37-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 140-142 °C
• Boiling Point: 295.9°C at 760 mmHg
• Flash Point: 147°C
• Density: 1.179g/cm³
• Vapor Pressure: 0.000843mmHg at 25°C
• Refractive Index: 1.584
• PKA: 10.10±0.23(Predicted)
• CAS DataBase Reference: 3-tert-butyl-2,5-dihydroxy-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyl-2,5-dihydroxy-benzaldehyde(192803-37-5)
• EPA Substance Registry System: 3-tert-butyl-2,5-dihydroxy-benzaldehyde(192803-37-5)

Safety Data

• Hazardous Substances Data: 192803-37-5(Hazardous Substances Data)

Usage

Description

3-tert-butyl-2,5-dihydroxy-benzaldehyde, also known as 3-(tert-butyl)-2,5-dihydroxybenzaldehyde, is a chemical compound with the molecular formula C13H16O3. It is a white to light yellow solid that exhibits a sweet, floral odor. 3-tert-butyl-2,5-dihydroxy-benzaldehyde is soluble in most organic solvents and is recognized for its applications in the synthesis of pharmaceuticals, organic compounds, fragrances, and flavors. Its utility in research for developing new drugs and bioactive compounds further underscores its importance in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
3-tert-butyl-2,5-dihydroxy-benzaldehyde serves as an intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows for the development of new drugs and other bioactive compounds, making it a valuable component in medicinal chemistry and drug discovery processes.
Used in Fragrance and Flavor Industry:
3-tert-butyl-2,5-dihydroxy-benzaldehyde is utilized in the production of a wide range of fragrances and flavors due to its distinctive sweet, floral scent. Its solubility in organic solvents facilitates its incorporation into different product formulations, enhancing the sensory attributes of consumer goods in this industry.
Used in Research and Development:
3-tert-butyl-2,5-dihydroxy-benzaldehyde is employed as a building block in research settings for the creation of innovative chemical entities. Its role in the development of new compounds underscores its importance in advancing scientific knowledge and contributing to the discovery of novel therapeutic agents.
Safety Note:
It is crucial to handle 3-tert-butyl-2,5-dihydroxy-benzaldehyde with care due to its potential harmful effects if ingested, inhaled, or absorbed through the skin. Proper safety measures should be implemented during its use to minimize health risks.

Upstream product

• 50-00-0 formaldehyd 
• 155135-23-2 2-(1,1-dimethylethyl)-4-(triisopropylsilyloxy)phenol 
• 246509-53-5 2-hydroxy-5-pivaloyloxy-3-tert-butylbenzaldehyde 
• 66549-79-9 3-(tert-butyl)-4-hydroxyphenyl pivalate 
• 1948-33-0 tert-butylhydroquinone 
• 3421-95-2 4-(benzyloxy)-2-(tert-butyl)phenol 
• 192803-36-4 5-benzyloxy-3-tert-butyl-2-hydroxy-benzaldehyde 
• 155135-24-3 3-tert-butyl-2-hydroxy-5-triisopropylsiloxybenzaldehyde 

Downstream Products

• 1612884-40-8 C₆₂H₈₂N₄O₁₁ 
• 1612884-44-2 (R,R)-N,N′-bis(3-tert-butyl-5-[3-methoxypropionyloxy]salicylidene)-1,2-cyclohexanediamine 
• 1612884-46-4 C₇₀H₉₄N₄O₁₅ 
• 1612884-37-3 3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid 
• 1612884-38-4 C₆₂H₇₈N₂O₁₆ 
• 336195-57-4 (R,R)-N,N′-bis(3-tert-butyl-5-hydroxysalicylidene)-1,2-cyclohexanediamine 
• 1612884-43-1 C₁₅H₂₀O₅ 
• 1241386-72-0 3-tert-butyl-5-formyl-4-hydroxyphenyl-11-(diethoxy(methyl)silyl)-undecanoate 

Relevant articles and documents

An Amphiphilic (salen)Co Complex – Utilizing Hydrophobic Interactions to Enhance the Efficiency of a Cooperative Catalyst

An amphiphilic (salen)Co(III) complex is presented that accelerates the hydrolytic kinetic resolution (HKR) of epoxides almost 10 times faster than catalysts from commercially available sources. This was achieved by introducing hydrophobic chains that increase the rate of reaction in one of two ways – by enhancing cooperativity under homogeneous conditions, and increasing the interfacial area under biphasic reaction conditions. While numerous strategies have been employed to increase the efficiency of cooperative catalysts, the utilization of hydrophobic interactions is scarce. With the recent upsurge in green chemistry methods that conduct reactions ‘on water’ and at the oil-water interface, the introduction of hydrophobic interactions has potential to become a general strategy for enhancing the catalytic efficiency of cooperative catalytic systems. (Figure presented.).

A broadly applicable and practical oligomeric (salen)Co catalyst for enantioselective epoxide ring-opening reactions

The (salen)Co catalyst (4a) can be prepared as a mixture of cyclic oligomers in a short, chromatography-free synthesis from inexpensive, commercially available precursors. This catalyst displays remarkable enhancements in reactivity and enantioselectivity relative to monomeric and other multimeric (salen)Co catalysts in a wide variety of enantioselective epoxide ring-opening reactions. The application of catalyst 4a is illustrated in the kinetic resolution of terminal epoxides by nucleophilic ring-opening with water, phenols, and primary alcohols; the desymmetrization of meso epoxides by addition of water and carbamates; and the desymmetrization of oxetanes by intramolecular ring opening with alcohols and phenols. The favorable solubility properties of complex 4a under the catalytic conditions facilitated mechanistic studies, allowing elucidation of the basis for the beneficial effect of oligomerization. Finally, a catalyst selection guide is provided to delineate the specific advantages of oligomeric catalyst 4a relative to (salen)Co monomer 1 for each reaction class.

POLYMERIC SALEN COMPOUNDS AND METHODS THEREOF

The present disclosure provides a polymerizable compound of the formula (I) where the R1, R2, R’1, R’2, X1 to X8, Y1, Y2, M and L have any of values as defined in the