3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

Base Information

Chemical Name:3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester
CAS No.:188885-04-3
Molecular Formula:C₁₈H₂₁N₃O₄
Molecular Weight:343.382
Hs Code.:

Synonyms:3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

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Chemical Property of 3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

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Technology Process of 3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

There total 6 articles about 3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1027037-55-3
3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-3-oxopropionic acid ethyl ester

: 188885-04-3
3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

Guidance literature:: With triethylamine; Methanesulfonyl azide; In acetonitrile; for 3h; Ambient temperature;
DOI:10.1021/jo962184z

Reference yield:

: 100-39-0
benzyl bromide

: 188885-04-3
3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH, NaI / tetrahydrofuran; paraffin / 1.) reflux, 1 h, 2.) reflux, 4 h

2: 3N KOH / methanol / 10 h / Ambient temperature

3: 1.) oxalyl chloride, DMF, 2.) n-BuMgCl / 1.) Et₂O, room temperature, 30 min, 2.) CH₂Cl₂, THF, 0 deg C, 1 h

4: 85 percent / Et₃N, MsN₃ / acetonitrile / 3 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; butyl magnesium bromide; sodium hydride; triethylamine; N,N-dimethyl-formamide; Methanesulfonyl azide; sodium iodide; In tetrahydrofuran; methanol; acetonitrile; paraffin;
DOI:10.1021/jo962184z

Reference yield:

: 29681-78-5
3-methyl-2-oxopiperidine-3-carboxylic acid ethyl ester

: 188885-04-3
3-(1-benzyl-3-methyl-2-oxopiperidin-3-yl)-2-diazo-3-oxopropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH, NaI / tetrahydrofuran; paraffin / 1.) reflux, 1 h, 2.) reflux, 4 h

2: 3N KOH / methanol / 10 h / Ambient temperature

3: 1.) oxalyl chloride, DMF, 2.) n-BuMgCl / 1.) Et₂O, room temperature, 30 min, 2.) CH₂Cl₂, THF, 0 deg C, 1 h

4: 85 percent / Et₃N, MsN₃ / acetonitrile / 3 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; butyl magnesium bromide; sodium hydride; triethylamine; N,N-dimethyl-formamide; Methanesulfonyl azide; sodium iodide; In tetrahydrofuran; methanol; acetonitrile; paraffin;
DOI:10.1021/jo962184z