(S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate
CAS No.:1335207-73-2
Molecular Formula:C₂₂H₂₃FN₂O₂
Molecular Weight:366.435
Hs Code.:

Synonyms:(S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

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Chemical Property of (S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

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Technology Process of (S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

There total 9 articles about (S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 21109-25-1
1-(1H-indol-2-yl)methanamine

: 24424-99-5
di-tert-butyl dicarbonate

: 459-57-4
4-fluorobenzaldehyde

: 1335207-73-2
(S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Guidance literature:: 1-(1H-indol-2-yl)methanamine; 4-fluorobenzaldehyde; With (S)-N-benzhydryl-2-{{2-{[3,5-bis(trifluoromethyl)phenyl]amino}-3,4-dioxocyclobut-1-en-1-yl}amino}-N,3,3-trimethylbutanamide; benzoic acid; In toluene; at 22 ℃; for 1h; Molecular sieve; Inert atmosphere;

di-tert-butyl dicarbonate; In toluene; at 22 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

In hexane; enantioselective reaction;
DOI:10.1002/adsc.202001472

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₇H₁₅FN₂

: 1335207-73-2
(S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

: (R)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Guidance literature:: In toluene; for 0.5h; Inert atmosphere;
DOI:10.1021/ol202300t

Reference yield:

: 21109-25-1
1-(1H-indol-2-yl)methanamine

: 24424-99-5
di-tert-butyl dicarbonate

: 459-57-4
4-fluorobenzaldehyde

: 1335207-73-2
(S)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

: (R)-tert-butyl 1-(4-fluorophenyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Guidance literature:: 1-(1H-indol-2-yl)methanamine; 4-fluorobenzaldehyde; With (S)-N-benzhydryl-2-{{2-{[3,5-bis(trifluoromethyl)phenyl]amino}-3,4-dioxocyclobut-1-en-1-yl}amino}-N,3,3-trimethylbutanamide; benzoic acid; In toluene; at 22 ℃; for 1h; Molecular sieve; Inert atmosphere;

di-tert-butyl dicarbonate; In toluene; at 22 ℃; for 0.5h; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1002/adsc.202001472