(1H-Indol-2-ylmethyl)amine

Base Information

• Chemical Name: (1H-Indol-2-ylmethyl)amine
• CAS No.: 21109-25-1
• Molecular Formula: C9H10N2
• Molecular Weight: 146.192
• Hs Code.: 2933990090
• Mol file: 21109-25-1.mol

Synonyms:Indole,2-(aminomethyl)- (6CI,8CI);1-(1H-Indol-2-yl)methanamine;2-Aminomethylindole;1H-Indole-2-methanamine;

Chemical Property of (1H-Indol-2-ylmethyl)amine

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Melting Point: 68-75°C
• Refractive Index: 1.697
• Boiling Point: 335.6 °C at 760 mmHg
• PKA: 17.33±0.30(Predicted)
• Flash Point: 183.3 °C
• PSA: 41.81000
• Density: 1.2 g/cm³
• LogP: 2.32690
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-(Aminomethyl)indole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Aminomethyl)indole is used as a pharmaceutical intermediate.

Technology Process of (1H-Indol-2-ylmethyl)amine

There total 13 articles about (1H-Indol-2-ylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1H-indole-2-carbonitrile (36193-65-4) → 1-(1H-indol-2-yl)methanamine (21109-25-1)

Guidance literature:

With sodium n-propoxide; In 1,2-dimethoxyethane; at 69.84 ℃; for 6h;

DOI:10.1007/s11164-012-0542-9

Reference yield:

1H-indole-2-carboxamide (1670-84-4) → 1-(1H-indol-2-yl)methanamine (21109-25-1)

Guidance literature:

With tetrahydrofuran; lithium aluminium tetrahydride;

DOI:10.1007/BF00906089

Reference yield:

1H-indole-2-carbonitrile (36193-65-4) + water (7732-18-5) → 1-(1H-indol-2-yl)methanamine (21109-25-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

upstream raw materials:

1H-indole-2-carboxamide

2,2,2-Trifluoro-N-(1H-indol-2-ylmethyl)-acetamide

1H-indole-2-carbaldehyde oxime

Indole-2-carboxylic acid

Downstream raw materials:

5-[(indol-2-ylmethyl-amino)-methyl]-2-methoxy-phenol

4-[(indol-2-ylmethyl-amino)-methyl]-1-methoxy-2-(3,4,5-trimethoxy-benzoyloxy)-benzene

N-2-Indolylmethyl-N'-methylthiourea

1-(1H-indol-2-ylmethyl)-3-phenyl-thiourea