3-Nitrophencyclidine

Base Information

• Chemical Name: 3-Nitrophencyclidine
• CAS No.: 70227-29-1
• Molecular Formula: C17H24N2O2
• Molecular Weight: 288.39
• Mol file: 70227-29-1.mol

Synonyms:1-[1-(3-Nitro-phenyl)-cyclohexyl]-piperidine;

Chemical Property of 3-Nitrophencyclidine

Chemical Property:

• Vapor Pressure: 1.15E-06mmHg at 25°C
• Boiling Point: 401.8°C at 760 mmHg
• Flash Point: 196.8°C
• PSA: 49.06000
• Density: 1.144g/cm³
• LogP: 4.70120

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Nitrophencyclidine

There total 1 articles about 3-Nitrophencyclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Phencyclidine (77-10-1) → 3-nitrophencyclidine (70227-29-1) + 4-nitrophencyclidine (60658-01-7)

Guidance literature:

With sulfuric acid; nitric acid; Yields of byproduct given; 1.) 0 deg C, 2.) 25 deg C, 1 h;

DOI:10.1021/jo00323a014

Reference yield: 88.0%

3-nitrophencyclidine (70227-29-1) → 3-aminophencyclidine (72242-00-3)

Guidance literature:

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; at 25 ℃; for 2h; under 1034.3 - 2585.7 Torr; other reducing agent;

DOI:10.1021/jo00323a014

Reference yield:

3-nitrophencyclidine (70227-29-1) → 1-Phenyl-3-[3-(1-piperidin-1-yl-cyclohexyl)-phenyl]-thiourea (76916-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂, 10percent aq. K₂CO₃ / 5percent Pd/C / ethanol / 2 h / 25 °C / 1034.3 - 2585.7 Torr / other reducing agent

2: triethylamine / dimethylsulfoxide / 2 h / 40 °C

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jo00323a014

upstream raw materials:

Phencyclidine

Downstream raw materials:

3-aminophencyclidine

3,3'-Bis<1-(1-piperidyl)cyclohexyl>azobenzene

1-Phenyl-3-[3-(1-piperidin-1-yl-cyclohexyl)-phenyl]-thiourea

Refernces